Diketo analogues and their significance

Published online Sep Received May 10; Accepted Sep 8.

Diketo analogues and their significance

Support Article How to avoid plagiarism? Make sure that you do not copy verbatim more than two words in a row from the text you have found. If you do use more than two words together, you will have to use quotation marks.

We will get into quoting properly soon. Cite - Citing is one of the effective ways to avoid plagiarism. Synthesis, characterization of some heterocyclic curcumin analogues and their copper complexes as antitubercular and antimicrobial agents strict warning: L and Mathew Paul The present paper enlighten the synthesis, characterization and biological significance of a series of 5-hetero aryl phenylpentene-1,3-diones 1a-c and their Cu II complexes 1d-f of ML2 stoichiometry.

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The synthesis of the titled derivatives was achieved by the condensation of benzoyl acetone with various heterocyclic aldehydes through boric anhydride mediated mechanism in the N-butyl amine induced basic medium.

Boric anhydride act by blocking the middle methylene group of benzoyl acetone and facilitating the condensation of lateral methyl group of benzoyl acetone with aromatic aldehydes, hence preventing facile Knoevenagel type of condensation.

Compound 1a-c belongs to the class of 1, 3-dicarbonyl compounds in which the diketo function is directly attached to olefinic carbon, conferring complexing properties to the molecules.

Analytical UV, IR, 1H NMR and mass spectral data of metal complexes suggest, the intermolecularly hydrogen bonded enol proton was replaced by the metal atom to produce copper complexes of ligands 1a-c. All the six derivatives were screened for antitubercular and antimicrobial activities by micro plate Alamar Blue assay and Kirby-Bauer disc plate method respectively.

Copper complexes of 1 a-c have shown significant antitubercular and antimicrobial activity when compared with standard drugs.

Diketo analogues and their significance

Further redox properties of metal when it is complexed with ligands were thought to be the reason for the increase sensitivity Cu II complexes as significant antitubercular and antimicrobial agents.Sunless tanning, also known as UV filled tanning, self tanning, spray tanning (when applied topically), or fake tanning, refers to the application of chemicals to the skin to produce an effect similar in appearance to a ashio-midori.com popularity of sunless tanning has risen since the s after health authorities confirmed links between UV exposure (from sunlight or tanning beds) and the.

diketo analogues and their significance Antibacterial The quinolones 3 are well known synthetic antibacterial agents with di keto moiety some examples are Ciprofloxacin (1) & . anhydrides are more resistant than their unsubstituted analogues (23).

Among the factors influencing the volume change accompanying same significance as in Fig. 1. mental one, indicating that the hydrolysis of both glycine and alanine anhydrides is accompanied by an increase in volume. contains their diketo form (34) the configurational.

A panel of viruses containing the diketo acid resistance mutations and the L, mutations were constructed and evaluated for their susceptibility to L, and diketo acid (2). Viruses containing mutations selected by L, were 4- to fold less sensitive to the inhibitor, and resistance was enhanced with the addition of those.

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RSC Advances PAPER Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the Cite this: RSC Adv., , 5, development of bacterial methionine aminopeptidase inhibitors Mir Mohammad Masood,a Vijay K.

Pillalamarri,b Mohammad Irfan,a Babita Aneja,a Mohamad Aman Jairajpuri,c Md. Zafaryab,d M. Moshahid A. Rizvi,d.

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